Travel to the Sanford (Hwy 46) exit. From the exit travel East towards Sanford. At the traffic light at 17/92 take a Right. Take a left on to 3rd Street. Follow 3rd Street to Palmetto. Left on Palmetto. On Palmetto, cross E. 1st Street. There will be a parking lot on your right.
From Orlando on 17/92:
Travel North on 17/92 into Sanford. Take a right on 3rd Street and follow directions above.
Here’s a map to the closest parking garage: